Evaluation of Thiol Disulfide Balance in Cervix Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 123
- 试验地点
- 1
- 主要终点
- serum native thiol level
研究概览
简要总结
The aim of this research is to evaluate thiol-disulfide balance in cervix cancer patients
详细描述
To date various oxidative stress parameters were studied in patients with cervix cancer, however dynamic thiol disulfide hemostasis has not been previously investigated.
The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel & Neselioglu (1).
References
1- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/j.clinbiochem.2014.09.026.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Histopathologically confirmed diagnosis of cervix cancer
排除标准
- •pulmonary disease
- •pulmonary hypertension
- •cardiac dysfunction
- •renal dysfunction
- •liver disease
- •chronic ischemia
- •systemic inflammation
- •concomitant malignancy
- •patients who use vitamin A,C or E (antioxidant vitamins)
- •patients who use smoke
- •patients who use drink alcohol
- •patients who use addictive for any drug
结局指标
主要结局
serum native thiol level
时间窗: preoperative in the morning or preprandial for healthy volunteers
serum native thiol level in μmol/L
disulphide/total thiol ratio
时间窗: preoperative in the morning or preprandial for healthy volunteers
disulphide/total thiol ratio X (100 )
serum total thiol level
时间窗: preoperative in the morning or preprandial for healthy volunteers
serum total thiol level in μmol/L
native thiol/total thiol ratio
时间窗: preoperative in the morning or preprandial for healthy volunteers
native thiol/total thiol ratio X (100 )
serum disulphide level
时间窗: preoperative in the morning or preprandial for healthy volunteers
serum disulphide level in μmol/L
the disulphide/native thiol ratio
时间窗: preoperative in the morning or preprandial for healthy volunteers
the disulphide/native thiol ratio X (100 )
次要结局
- total oxidant capacity (TOC)(preoperative in the morning or preprandial for healthy volunteers)
- Oxidative stress index (OSI)(preoperative in the morning or preprandial for healthy volunteers)
- ischaemia-modified albumin(preoperative in the morning or preprandial for healthy volunteers)
- total antioxidant capacity (TAC)(preoperative in the morning or preprandial for healthy volunteers)
研究者
Burak Sezgin
Principal Investigator
Muğla Sıtkı Koçman University