Assessment of Thiol Disulfide Balance in Early Stage Endometrium Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 117
- 试验地点
- 1
- 主要终点
- native thiol/total thiol ratio
研究概览
简要总结
The purpose of this study is to investigate thiol-disulfide balance in early stage endometrium cancer patients.
详细描述
To date various oxidative stress paramaters were studied in patients with endometrial cancer, however dynamic thiol disulfide hemostasis has not been previously investigated.
The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel & Neselioglu(1).
References
1- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/j.clinbiochem.2014.09.026.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Histopathologically confirmed diagnosis of stage I endometrium cancer
排除标准
- •pulmonary disease
- •pulmonary hypertension
- •cardiac dysfunction
- •renal dysfunction
- •liver disease
- •chronic ishemia
- •systemic inflammation
- •concomitant malignancy
- •patients who use vitamin A,C or E (antioxidant vitamins)
- •patients who use smoke
- •patients who use drink alcohol
- •patients who use addictive for any drug
结局指标
主要结局
native thiol/total thiol ratio
时间窗: preoperative in the morning or preprandial for healthy volunteers
native thiol/total thiol ratio X (100 )
serum total thiol level
时间窗: preoperative in the morning or preprandial for healthy volunteers
serum total thiol level in μmol/L
serum native thiol level
时间窗: preoperative in the morning or preprandial for healthy volunteers
serum native thiol level in μmol/L
serum disulphide level
时间窗: preoperative in the morning or preprandial for healthy volunteers
serum disulphide level in μmol/L
the disulphide/native thiol ratio
时间窗: preoperative in the morning or preprandial for healthy volunteers
the disulphide/native thiol ratio X (100 )
disulphide/total thiol ratio
时间窗: preoperative in the morning or preprandial for healthy volunteers
disulphide/total thiol ratio X (100 )
次要结局
- total oxidant capacity (TOC)(preoperative in the morning or preprandial for healthy volunteers)
- Oxidative stress index (OSI)(preoperative in the morning or preprandial for healthy volunteers)
- total antioxidant capacity (TAC)(preoperative in the morning or preprandial for healthy volunteers)
研究者
Burak Sezgin
Principal Investigator
Muğla Sıtkı Koçman University