Serum Thiol/Disulphide Homeostasis Level and Its Correlation With the Severity of Preeclampsia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Thiol/ disulfide hemostasis
研究概览
简要总结
Objective: To evaluate serum evaluate thiol/ disulfide levels in preeclampsia and address its relationship with its severity.
Methods: This prospective study will include 50 pregnancies complicated with preeclampsia and 50 healthy pregnancies. The blood for analysis will obtain at the admission and serum thiol/ disulfide levels will measure using commercially available reagent kits. The continuous values were evaluated using Student's t-test, and categorical values were evaluated using the Chi-square test. P values < .05 were accepted as significant.
详细描述
This is an observational prospective cohort study will conduct at Obstetrics and Gynecology Department of Cengiz Gokcek Obstetrics and Children's Hospital between April and October 2019. One hundred women will enrol in the study in two groups. We will consecutively recruit 50 pregnancies complicated with preeclampsia, and 50 healthy pregnancies will select for the control group. All patients will give their oral and written informed consent before their inclusion in the study. The protocol was approved by the Ethics Committee for Clinical Research of Gaziantep University (Reference number: 2019/147). The study strictly will adhere to the principles of the Declaration of Helsinki.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •preeclampsia
- •healthy pregnancy
排除标准
- •pregnant women with any systemic condition (such as chronic hypertension, diabetes mellitus, thyroid diseases, liver and kidney diseases)
- •women with a history of drug use throughout pregnancy
- •history of medication for PE treatment at the time of first admission
- •patients who had fetal congenital abnormalities or genetic syndromes
- •multiple gestation
- •active labor
结局指标
主要结局
Thiol/ disulfide hemostasis
时间窗: 1 day
The primary endpoint in this analysis is to evaluate thiol/disulfide levels in preeclampsia and address its relationship with its severity.
次要结局
未报告次要终点
研究者
Ali Ovayolu
Principal Investigator
Cengiz Gokcek Women's and Children's Hospital