Comparison of effectiveness between autologous Platelet-rich plasma and autologous fat with Platelet-rich fibrin in injection laryngoplasty for patients with unilateral vocal fold paralysis
Phase 3
Recruiting
- Conditions
- Patients with unilateral vocal fold paralysisunilateral vocal fold paralysis, injection laryngoplasty ,Platelet-rich plasma, Fat, Platelet-rich fibrin
- Registration Number
- TCTR20230227001
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
1.Unilateral vocal fold paralysis patients with 6 months onset is considered to injection laryngoplasty for treatment
2.Willing to give consent
Exclusion Criteria
1.Age < 18 years
2.Patients with bleeding tendency or coagulopathy.
3.Patient isn't able to follow up as research protocol.
4.Patients received phonosurgery before.
5.Organic lesions were found, e.g., vocal polyps, vocal tumor, vocal cyst,or glottic cancer.
6.Patients with cricoarytenoid joint fixation or fibrosis at posterior vocal cord.
7.Patients who don't have enough fat for harvestment.
8.Patients who refuse to enroll the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Voice handicap index (VHI) preoperative, postoperative at 1 month and 6 month Questionnaire of VHI score
- Secondary Outcome Measures
Name Time Method Jitter preoperative, postoperative at 1 month and 6 month Dr.speech equipment,Shimmer preoperative, postoperative at 1 month and 6 month Dr.speech equipment,NHR preoperative, postoperative at 1 month and 6 month Dr.speech equipment,MPT preoperative, postoperative at 1 month and 6 month Dr.speech equipment