Efficacy of Silymarin and Vitamin E in the Treatment fatty liver
- Conditions
- K75.81on-Alcoholic Fatty Liver Disease.Nonalcoholic steatohepatitis (NASH)
- Registration Number
- IRCT20081110001444N6
- Lead Sponsor
- Shahid Sadoughi University of Medical Sciences-Yazd, Iran
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
The inclusion criteria were : NAFLD confirmed through abdominal ultrasonography, persistent elevation in the level of alanine aminotransferase (ALT) within the last six months for one and a half times more than the upper normal limit, fatty changes diagnosed through ultrasonography, and over 20 years of age.
The exclusion criteria were autoimmune hepatitis, alpha-1 antitrypsin deficiency, chronic hepatitis B or C, hemochromatosis, and Wilson’s disease. Patients with a history of diabetes, daily consumption ethanol, severe cardiac, pulmonary, renal, or psychological problems, positive pregnancy test, and the use of drugs such as statins, fibrates, anti-convulsants, NSAID, acetaminophen, warfarin, metronidazole, anti-depressants, or anti-psychotics were also excluded from the study.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ALanin aminotransferas measurements. Timepoint: They were received at the baseline and then after four months for ALT measurements. Method of measurement: autoanlizer.;Ultrasonographic evaluations of their liver. Timepoint: first and four months later. Method of measurement: General Electric ultrasound device,.
- Secondary Outcome Measures
Name Time Method