Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery
Overview
- Phase
- Phase 4
- Intervention
- propofol, sevoflurane
- Conditions
- Hyperalgesia
- Sponsor
- Gangnam Severance Hospital
- Enrollment
- 84
- Locations
- 1
- Primary Endpoint
- Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs
- Last Updated
- 15 years ago
Overview
Brief Summary
The investigators hypothesize that propofol infusion during surgery can affect the remifentanil hyperalgesia compared to sevoflurane inhalation.The outcome will be measured by a verbal numerical rating score (VNRS) and mechanical punctuating pain by electronic von frey filament.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing thyroidectomy
- •Age 20-65
- •American Society of Anesthesiologists physical status classification I or II
Exclusion Criteria
- •History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs
- •History of drug \& alcohol abuse
- •Psychiatric disorder
- •Use of opioids within 24hrs
- •Renal disease with decreased glomerular filtrate ratio
- •Neuromuscular disease, Severe cardiac disease
Arms & Interventions
sevoflurane
Remifentanil will be infused intraoperatively at 0.2 ㎍/㎏/min. patients who are in this group will be infused propofol intraoperatively.
Intervention: propofol, sevoflurane
propofol
Remifentanil will be infused intraoperatively at 0.2 ㎍/㎏/min. patients included this group will be inhaled sevoflurane intraoperatively.
Intervention: propofol, sevoflurane
Outcomes
Primary Outcomes
Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs
Time Frame: postoperative 48 hrs