Body composition, mitochondrial oxygen metabolism and metabolome of obese patients before and after bariatric surgery
Not Applicable
- Conditions
- E66.99 overweight and obesity
- Registration Number
- DRKS00015891
- Lead Sponsor
- WG Translational Septomics, Zentrum für Innovationskomepetenz (ZIK) Septomics, Universitätklinikum Jena
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 65
Inclusion Criteria
1.) Grad 3 obesity with BMI =40 kg/m2 and significant metabolic comorbidity, EOSS (Edmonton Obesity Staging System) stage = 2 with truncal obesity
2.) written informed consent
Exclusion Criteria
1.) Contra-indications to bio-impedance and COMET analysis
2.) Pregnancy or breastfeeding period
3.) Participation in another interventional study
4.) Prior participation in this study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in relative fat mass 6 months after surgery compared with the pre-operative state.
- Secondary Outcome Measures
Name Time Method 1.) Change in mitochondrial oxygen metabolism (mitoPO2, mitoVO2 and mitoDO2) 6 and 12 months after surgery compared with before the operation. <br>2.) Explorative analyses of the relationship between bio-impedance analysis parameters and mitoPO2 and mitoVO2 values 6 and 12 months after surgery compared with before the operation. <br>3.) Changes in body composition, especially visceral fat and muscle mass before the operation compared with 3, 6, 9 and 12 months after. <br>4.) Influence of bariatric surgery on laboratory parameters, specifically metabolome, lipidome, immune function and epigenetics. <br>