To compare effect of nor epinephrine and phenylephrine in cases of blood pressure decrease in pregnant women undergoing emergency cesarean section under spinal anaesthesia.
Phase 4
- Conditions
- Health Condition 1: 1- Obstetrics
- Registration Number
- CTRI/2023/07/055528
- Lead Sponsor
- Dr Rajat Kathpal
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Those parturients who will develop hypotension after subarachnoid block, with systolic blood pressure being <20% of the baseline value will be included in the study.
Exclusion Criteria
Parturients with:-
1.Fetal Abnormality.
2.Preexisting or Pregnancy Induced Hypertension.
3.Known Cardiovascular or Cerebrovascular Disease.
4.Thrombocytopenia.
5.Coagulopathy or any medical contraindication to spinal anesthesia.
6.Weight <50 kg or >100kg.
7.Height <140 cm or >180 cm.
8.Parturient using monoamine oxidase inhibitors or tricyclic anti-depressants.
9.Parturient allergic to study drug.
10.Refusal of informed consent.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Haemodynamic Changes: <br/ ><br>Blood pressure & HR will be monitored every 2 mins till 10 min, & thereafter every 5 min till the end of surgery. <br/ ><br>Incidence of hypotension, bradycardia, tachycardia, hypertension will be noted. <br/ ><br>2.No. of boluses of vasopressor agents given intraoperatively will be noted. <br/ ><br>Timepoint: From administration of sub arachnoid block to end of surgery.
- Secondary Outcome Measures
Name Time Method 1.Fetal Outcome: <br/ ><br>A paediatrician who will not be aware of the vasopressor used will note: <br/ ><br>a) APGAR SCORE:- at 1 min & 5 mins. <br/ ><br>b) Fetal Acidosis:- Umbilical arterial sample will be collected at the time of birth to analyse pH. Fetal acidosis will be defined as pH less than 7. <br/ ><br>2.Complications if any: <br/ ><br>Incidence of dizziness, nausea, vomiting or shivering due to maternal hypotension will also be noted. <br/ ><br>Timepoint: From administration of sub arachnoid block to end of surgery.