To Compare Inflammatory Marker levels and Magnetic Resonance Spectroscopy Characteristics in Liver Cirrhotics with Minimal And Grade 1 Hepatic Encephalopathy
- Conditions
- Health Condition 1: K740- Hepatic fibrosis
- Registration Number
- CTRI/2023/10/059338
- Lead Sponsor
- Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients with evidence of cirrhosis on ultrasound, fibroscan or liver histopathology if available
Contraindications of MR spectroscopy including cardiac pacemaker without MRI compatibility, implanted cardioverter defibrillator, cochlear implant, claustrophobia etc.
Pregnancy
Patients with hepatic encephalopathy of Grade 2 or higher (By West Haven criteria) in the pastHistory of GI bleed in last one-month, spontaneous bacterial peritonitis (SBP) on prophylaxis or hepatorenal syndrome (HRS) and patients of acute on chronic liver failure (ACLF).
Patients who have received Lactulose, Rifaximin, LOLA, probiotics or anti-inflammatory drugs such as steroids and NSAIDs.
History of use of psychotropic drugs in last 6 weeks
Poor vision precluding neuropsychological assessment.
Patients with known neurological illness
History of TIPSS or Shunt surgery
Active ongoing infection
Hepatocellular carcinoma or severe medical problems such as congestive heart failure, pulmonary disease, or neurological or psychiatric disorder.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method