eural mechanisms of movement, balance and spatial orientation in health and disease
- Conditions
- Balance, dizziness and spatial disorientationNervous System Diseases
- Registration Number
- ISRCTN16535836
- Lead Sponsor
- Imperial College Healthcare NHS Trust
- Brief Summary
2022 Other publications in http://dx.doi.org/10.1136/jnnp-2022-328997 (added 21/09/2023) 2022 Results article in https://doi.org/10.1016/j.jns.2022.120458 (added 21/09/2023) 2021 Results article in https://doi.org/10.1093/brain/awaa386 (added 21/09/2023)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 225
Patients
1. Injury to the brain and its sensorium (including eyes, ears, proprio-somatosenory system) from trauma, inflammation and/or disturbed vascular supply
2. Age 18-75
3. Male or Female
Controls
1. Healthy individual
2. Age 18-75
3. Male or Female
Patients
1. Premorbid acute or chronic medical condition that might impair balance and/or spatial orientation (e.g. previous peripheral or central vestibular disturbances)
2. Premorbid active psychiatric, neurological or neuro-otological condition
3. Premorbid substance abuse
Controls
1. Chronic medical condition requiring drug therapy (healthy controls with a past history of migraine in remission will be admissible)
2. Premorbid acute or chronic medical condition that might impair balance and/or spatial orientation (e.g. previous peripheral or central vestibular disturbances)
3. Premorbid active psychiatric, neurological or neuro-otological condition
4. Premorbid substance abuse
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Functional independence is measured using the Functional Independence Measure (‘FIM’) score at 6 months <br>2. Cumulative falls over 6 months are measured monthly by reviewing patient diaries either via telephone or by email (or face-to-face during the two follow-up sessions)
- Secondary Outcome Measures
Name Time Method