The Association Between the Intraoperative Blood Pressure Changes and Whole Exome Genome

Not yet recruiting

• Conditions: the Association Between the Arterial Stiffness, Intraoperative Blood Pressure Changes and Genetic Effect
• Interventions: Other: this study did not involve interventions; it only observational study

• Registration Number: NCT05730140
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The intraoperative blood pressure changes have been important for postoperative morbidity and mortality. However, some patients did not occur intraoperative hypotension but some patients would have severe intraoperative hypotension. It may be associated with genome related. In this hypothesis, we aim to elucidate the association between the whole exome genome and intraoperaive blood pressure changes.

Detailed Description

We aim to elucidate the association between the whole exome genome and intraoperative blood pressure changes.

We will enroll patients older than 20 years old and undergo elective general anesthesia.

Before anesthesia, we will obtain blood sample for whole exome genome test and give arterial line for intraoperative monitor.

After completing surgery, we will follow the patients' all postoperative major organ function.

We hope this study to be able to give us the more information about the specific genetic effect on the arterial stiffness and intraoperative blood pressure changes.

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2023-02
• Study First Submitted: 2023-02-07
• Study First Submitted QC: 2023-02-07
• Last Update Submitted: 2023-02-07
• Study Start: 2023-02-10
• Study First Posted: 2023-02-15
• Last Update Posted: 2023-02-15
• Primary Completion: 2028-12-31
• Study Completion: 2030-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• elective general surgery

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Exclusion Criteria

• coagulopathy

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients undergoing general anesthesia	this study did not involve interventions; it only observational study	patients undergoing general anesthesia

Primary Outcome Measures

Name	Time	Method
The association between the arterial stiffness and whole exome genome	15 minutes	using pearson correlation to describe the association