Association Between Whole Exon Sequencing and Arterial Stiffness in Patients With Intraoperative Hypotension)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 主要终点
- The association between the arterial stiffness and whole exome genome
研究概览
简要总结
The intraoperative blood pressure changes have been important for postoperative morbidity and mortality. However, some patients did not occur intraoperative hypotension but some patients would have severe intraoperative hypotension. It may be associated with genome related. In this hypothesis, we aim to elucidate the association between the whole exome genome and intraoperaive blood pressure changes.
详细描述
We aim to elucidate the association between the whole exome genome and intraoperative blood pressure changes.
We will enroll patients older than 20 years old and undergo elective general anesthesia.
Before anesthesia, we will obtain blood sample for whole exome genome test and give arterial line for intraoperative monitor.
After completing surgery, we will follow the patients' all postoperative major organ function.
We hope this study to be able to give us the more information about the specific genetic effect on the arterial stiffness and intraoperative blood pressure changes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •elective general surgery
排除标准
- •coagulopathy
结局指标
主要结局
The association between the arterial stiffness and whole exome genome
时间窗: 15 minutes
using pearson correlation to describe the association
次要结局
未报告次要终点