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临床试验/NCT05155514
NCT05155514已完成不适用

Comparison of the Relationship Between Preoperatively Measured Pulse Wave Velocity and Hemodynamic Changes During Anesthesia Induction in Hypertensive and Normotensive Patients.

Aydin Adnan Menderes University1 个研究点 分布在 1 个国家目标入组 139 人开始时间: 2018年11月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
139
试验地点
1
主要终点
Difference between hemodynamic values

研究概览

简要总结

Hypertension is a disease with increasing and serious complications all over the world. In particular, the incidence of hypertension increases with advancing age. Secondary problems that can be caused by hypertension include peripheral vascular diseases, arteriosclerosis, increased risk of heart attack and stroke. It is a measurement of pulse wave velocity (PWV), a non-invasive indicator of arterial stiffness. It is known that sudden hemodynamic changes that occur during the induction of anesthesia cause undesirable intraoperative and postoperative complications. It is known that arterial stiffness, which is more common in elderly patients, causes orthostatic hypotension in particular. For this reason, more hemodynamic instability may be seen in the general anesthesia procedure in elderly patients with increased arterial stiffness.

In our study, we aimed to investigate whether the hemodynamic changes observed during anesthesia induction in hypertensive elderly patients, whom we think have a high pulse wave velocity, are different from normotensive patients.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
50 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • According to the American Society of Anesthesiologists (ASA), physical condition I-II,
  • Elective otolaryngology surgery with endotracheal intubation planned
  • Patients aged 50 and over

排除标准

  • Hypersensitivity to drugs
  • Difficult intubation history
  • Diabetes mellitus receiving insulin therapy
  • Chronic renal failure or end-stage renal disease
  • Heart failure (left ventricular ejection fraction ≤30%)
  • Valve disease (moderate to severe)
  • Atrial fibrillation

结局指标

主要结局

Difference between hemodynamic values

时间窗: Basal measurement before induction of anesthesia, then at 1-minute intervals until after endotracheal intubation

The difference between the hemodynamic values measured preoperatively and during anesthesia induction was calculated. In addition, ≥20% decrease in preoperative hemodynamic value and/or systolic blood pressure ≤90 mmHg hypotension, ≥20% increased hypertension

次要结局

未报告次要终点

研究者

发起方
Aydin Adnan Menderes University
申办方类型
Other
责任方
Principal Investigator
主要研究者

SİNAN YILMAZ

Associate Professor

Aydin Adnan Menderes University

研究点 (1)

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