Pulse Wave Velocity and Hemodynamic Response During Anesthesia Induction in Hypertensive Patients

Completed

• Conditions: Arterial Stiffness
• Interventions: Procedure: Mobil-O-Graph PWA

• Registration Number: NCT05155514
• Lead Sponsor: Aydin Adnan Menderes University

Brief Summary

Hypertension is a disease with increasing and serious complications all over the world. In particular, the incidence of hypertension increases with advancing age. Secondary problems that can be caused by hypertension include peripheral vascular diseases, arteriosclerosis, increased risk of heart attack and stroke. It is a measurement of pulse wave velocity (PWV), a non-invasive indicator of arterial stiffness. It is known that sudden hemodynamic changes that occur during the induction of anesthesia cause undesirable intraoperative and postoperative complications. It is known that arterial stiffness, which is more common in elderly patients, causes orthostatic hypotension in particular. For this reason, more hemodynamic instability may be seen in the general anesthesia procedure in elderly patients with increased arterial stiffness.

In our study, we aimed to investigate whether the hemodynamic changes observed during anesthesia induction in hypertensive elderly patients, whom we think have a high pulse wave velocity, are different from normotensive patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-01
• Primary Completion: 2019-11-01
• Study Completion: 2020-11-01
• Status Verified: 2021-12
• Study First Submitted: 2021-12-03
• Study First Submitted QC: 2021-12-03
• Last Update Submitted: 2021-12-03
• Study First Posted: 2021-12-13
• Last Update Posted: 2021-12-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 139

Inclusion Criteria

• According to the American Society of Anesthesiologists (ASA), physical condition I-II,
• Elective otolaryngology surgery with endotracheal intubation planned
• Patients aged 50 and over

Exclusion Criteria

• Hypersensitivity to drugs
• Difficult intubation history
• Diabetes mellitus receiving insulin therapy
• Chronic renal failure or end-stage renal disease
• Heart failure (left ventricular ejection fraction ≤30%)
• Valve disease (moderate to severe)
• Atrial fibrillation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group H	Mobil-O-Graph PWA	Hypertension group (Group H): * Patients with a previous diagnosis of hypertension * Patients receiving antihypertensive therapy * Systolic blood pressure (SBP) ≥140mmHg and/or diastolic blood pressure (DBP) ≥90mmHg
Group N	Mobil-O-Graph PWA	Normotensive group (Group N): Other non-hypertensive patients

Primary Outcome Measures

Name	Time	Method
Difference between hemodynamic values	Basal measurement before induction of anesthesia, then at 1-minute intervals until after endotracheal intubation	The difference between the hemodynamic values measured preoperatively and during anesthesia induction was calculated. In addition, ≥20% decrease in preoperative hemodynamic value and/or systolic blood pressure ≤90 mmHg hypotension, ≥20% increased hypertension

Trial Locations

Locations (1)

Aydın Adnan Menderes University Faculty of Medicine, Department of Anesthesiology and Reanimation; 🇹🇷 Aydın, Turkey