Comparison of the Relationship Between Preoperatively Measured Pulse Wave Velocity and Hemodynamic Changes During Anesthesia Induction in Hypertensive and Normotensive Patients.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 139
- 试验地点
- 1
- 主要终点
- Difference between hemodynamic values
研究概览
简要总结
Hypertension is a disease with increasing and serious complications all over the world. In particular, the incidence of hypertension increases with advancing age. Secondary problems that can be caused by hypertension include peripheral vascular diseases, arteriosclerosis, increased risk of heart attack and stroke. It is a measurement of pulse wave velocity (PWV), a non-invasive indicator of arterial stiffness. It is known that sudden hemodynamic changes that occur during the induction of anesthesia cause undesirable intraoperative and postoperative complications. It is known that arterial stiffness, which is more common in elderly patients, causes orthostatic hypotension in particular. For this reason, more hemodynamic instability may be seen in the general anesthesia procedure in elderly patients with increased arterial stiffness.
In our study, we aimed to investigate whether the hemodynamic changes observed during anesthesia induction in hypertensive elderly patients, whom we think have a high pulse wave velocity, are different from normotensive patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •According to the American Society of Anesthesiologists (ASA), physical condition I-II,
- •Elective otolaryngology surgery with endotracheal intubation planned
- •Patients aged 50 and over
排除标准
- •Hypersensitivity to drugs
- •Difficult intubation history
- •Diabetes mellitus receiving insulin therapy
- •Chronic renal failure or end-stage renal disease
- •Heart failure (left ventricular ejection fraction ≤30%)
- •Valve disease (moderate to severe)
- •Atrial fibrillation
结局指标
主要结局
Difference between hemodynamic values
时间窗: Basal measurement before induction of anesthesia, then at 1-minute intervals until after endotracheal intubation
The difference between the hemodynamic values measured preoperatively and during anesthesia induction was calculated. In addition, ≥20% decrease in preoperative hemodynamic value and/or systolic blood pressure ≤90 mmHg hypotension, ≥20% increased hypertension
次要结局
未报告次要终点
研究者
SİNAN YILMAZ
Associate Professor
Aydin Adnan Menderes University
