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临床试验/NCT04433416
NCT04433416已完成不适用

Effect of Preoperative Hypertension and Controlled Hypotension on Postoperative Delirium in the Elderly

Zhang Lei1 个研究点 分布在 1 个国家目标入组 98 人开始时间: 2020年6月14日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
98
试验地点
1
主要终点
Degree of delirium

研究概览

简要总结

Comparision of Exposed Factors of Preoperative Hypertension and Intraoperative Controlled Hypotension on Postoperative Delirium in the Elderly under Radical Resection of Head, Neck and Maxillofacial Tumor

详细描述

Postoperative delirium has a higher incidence in elderly patients after general anesthesia,and It is closely related to the type of surgery, the length of surgery, and the patient's physique.Because head and neck maxillofacial radical surgery requires free flap transplantation and longer duration,and hemorrhage is more when the primary focus is removed,Intraoperative blood pressure reduction is needed to reduce bleeding,therefore, hypoperfusion of craniocerebral blood flow will occur.Low cerebral perfusion is closely related to the occurrence of postoperative delirium.Patients undergoing this type of surgery have more preoperative complications,hypertension is particularly common.Therefore, this study mainly studied the correlation between the preoperative blood pressure level and the controlled hypotension level in patients with radical head and neck and maxillofacial tumors and the incidence of postoperative delirium.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
60 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients who underwent radical anesthesia for oral and maxillofacial malignant tumors in our hospital
  • ASA grade is Ⅰ-Ⅱ
  • Patient is older than 60 years

排除标准

  • The patient has mental and mental disorders (eg schizophrenia, Alzheimer's disease)
  • There was severe anemia before operation (Hb<80g/L)
  • Patients had cerebral vascular complications such as cerebral infarction and lacunar infarction before operation
  • Patients who do not cooperate with this trial
  • Long-term use of sedative drugs or analgesics

结局指标

主要结局

Degree of delirium

时间窗: up to three days after surgery

From the first to the third day after surgery, the patient will be evaluated for delirium using the CAM scale.

次要结局

未报告次要终点

研究者

发起方
Zhang Lei
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Zhang Lei

Deputy Chief Physician and Associate Researcher

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

研究点 (1)

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