Effect of melatonin on the reduction of oxidative stress and the prevention of contrast-induced acute kidney injury
- Conditions
- Patients undergoing PCI with chronic kidney disease stage 3-5 (non-dialysis) with estimated glomerular filtration rate (eGFR) below than 60 mL/min/1.73 m2 measured by CKD-EPI methodContrast-induced acute kidney injury, Oxidative stress, Mitochondria, Prevention, Melatonin
- Registration Number
- TCTR20210123004
- Lead Sponsor
- Cardiac Electrophysiology Research and Training Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
1. Age more than 18 years old
2. Undergoing PCI
3. CKD stage 3-5 (non-dialysis) with estimated glomerular filtration rate (eGFR) below than 60 mL/min/1.73 m2 measured by CKD-EPI method
-ESRD on long term renal replacement therapy
-AKI with renal replacement therapy
-Receiving contrast media within 5 days
-Acute coronary syndrome within 5 days
-Acute decompensated heart failure
-Life-threatening cardiac arrhythmia (including ventricular tachycardia and ventricular fibrillation)
-Cardiac arrest
-Cardiogenic shock
-Sepsis or septic shock
-Active malignancy
-Volume of contrast in mL <3 times of eGFR
-Lupus nephritis
-Autosomal dominant polycystic kidney disease
-Severe anemia with hemoglobin <7 mg/dL
-Prior treatment with melatonin and other antioxidants; such as vitamin C, curcumin, and herbal medicine; in past 5 days
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction of oxidative stress and acute kidney injury biomarker 12 months after end of the intervention Urine NGA
- Secondary Outcome Measures
Name Time Method Oxidative stress 12 months after end of the intervention Mitochondrial antioxidant and oxidative stress