The effects of melatonine in high risk pregnant women receiving enoxaparin and aspiri

Phase 2

Recruiting

Conditions: High risk pregnant women receiving prophylaxis enoxaparin and aspirin.
Encounter for supervision of other normal pregnancy
Z34.8

Registration Number: IRCT20210608051518N1

Lead Sponsor: Yasouj University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 50

Inclusion Criteria

Pregnant women 15 to 45 years old
Gestational age between 6 to16 weeks
BMI more than 25 kg/m2
Start of taking anticoagulants and aspirin from the first half of pregnancy

Exclusion Criteria

Patients with diabetes mellitus receiving insulin or oral tablets
Chronic metabolic diseases
Anemia
Smokers and alcoholics
Use of other dietary supplements, probiotics and anti-inflammatory drugs
Use of any antioxidant supplements in the last 3 months
Use of immunosuppressive drugs
Following of special diets
History of taking OCP pills
Twin pregnancies or more
Gestational hypertension and diabetes

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
C-reactive protein. Timepoint: Before and after the intervention. Method of measurement: ELISA.

Secondary Outcome Measures

Name	Time	Method
Total antioxidant capacity. Timepoint: Before and after the intervention. Method of measurement: ELISA.;Malondialdehyde (MDA). Timepoint: Before and after the intervention. Method of measurement: ELISA.;Nitric oxide metabolites. Timepoint: Before and after the intervention. Method of measurement: ELISA.;Sulfhydryl protein. Timepoint: Before and after the intervention. Method of measurement: ELISA.;Baby head circumference. Timepoint: After the delivery. Method of measurement: Tape meter.;Baby height. Timepoint: After the delivery. Method of measurement: Digital scales.;Baby weight. Timepoint: After the delivery. Method of measurement: Digital scales.