The influence of synovialitis on the clinical outcome of knee joint preserving surgery.

Recruiting

• Conditions: M23; S83.50; M23.9; Internal derangement of knee; Internal derangement of knee, unspecified

• Registration Number: DRKS00029949
• Lead Sponsor: niversitätsklinikum Freiburg Klinik für Orthopädie und Unfallchirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-08-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

1) Upcoming joint-preserving knee joint surgery (arthroscopic and open): Partial meniscus resection, anterior cruciate ligament replacement surgery, cartilage reconstructive surgery (any technique).
3) Capacity to give consent
4) Participation in the DART registry (can also be done just prior to study inclusion).

Exclusion Criteria

1) Autoimmune diseases
2) Concomitant injury to the extremity on which the knee joint procedure is scheduled.
3) Acquired (i.e., drug-induced) immunosuppression (excluding perioperative use of NSAIDs).
4) Congenital immunosuppression

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of the severity of knee joint synovitis (inflammation of the synovium) at the time of surgery with postoperative clinical outcome by regression analysis.<br><br>H0: The severity of synovitis at the time of surgery does not correlate with clinical outcome.<br><br>H1: The severity of synovitis at the time of surgery correlates with clinical outcome.

Secondary Outcome Measures

Name	Time	Method
If, according to H1, there is a correlation of the severity of knee joint synovitis (inflammation of the synovium according to Krenn 0-9) at the time of surgery with the clinical outcome or the radiological outcome, factors predictive of outcome will be identified.<br><br>Correlation of the expression of knee joint synovitis (inflammation of the synovium according to Krenn 0-9) at the time of the operations with the initial MRI of the knee joint. <br><br>Correlation of the degree of knee joint synovialitis with the individual clinical pictures, e.g. meniscus lesion, anterior cruciate ligament rupture, cartilage damage.