Dietary Patterns, Inflammation, Zinc Status, and Body Composition in Multi-Ethnic Women of Reproductive Age in Jakarta

Recruiting

• Conditions: Body Composition; Dietary Analysis; Zinc Status; Blood Pressure; TNF Alpha

• Registration Number: NCT07170904
• Lead Sponsor: Indonesia University

Brief Summary

This study aims to determine the relationship between dietary patterns and hair zinc levels with body composition, tumor necrosis factor alpha (TNF-α), and blood pressure in women of reproductive age from different ethnic backgrounds in Jakarta, Indonesia (specifically Minangkabau, Sundanese, Javanese, Betawi, and Chinese). Participants are assessed once through dietary assessment, anthropometric measurements, and biological sample collection.

Detailed Description

This cross-sectional observational study will evaluate dietary patterns and their association with nutritional status and inflammation in women of reproductive age. Participants will undergo dietary intake assessments (including the SQ-FFQ and a 3-day food diary), anthropometric and body composition measurements using the BOD POD (weight, height, fat mass, fat-free mass), and biospecimen sampling (blood and hair) for laboratory analysis of TNF-α and hair zinc concentrations. These findings are expected to offer information about dietary determinants and zinc micronutrient status that influence body composition, inflammation, and blood pressure in urban reproductive-age women from diverse ethnic backgrounds.

Study Timeline

• Study Start: 2025-02-03
• Status Verified: 2025-09
• Study First Submitted: 2025-09-05
• Study First Submitted QC: 2025-09-05
• Last Update Submitted: 2025-09-05
• Study First Posted: 2025-09-12
• Last Update Posted: 2025-09-12
• Primary Completion: 2025-12-30
• Study Completion: 2026-03-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 188

Inclusion Criteria

• Women aged 19-49 years
• Residing in Jakarta for at least 6 months
• Currently menstruating (not menopausal)
• From Minangkabau, Sundanese, Javanese, Betawi, or Chinese ethnicity
• Not pregnant or breastfeeding at the time of study

Exclusion Criteria

• History of chronic diseases (e.g., diabetes, cardiovascular disease, cancer)
• Currently on a medically prescribed diet or taking medication affecting nutrient status
• Any condition interfering with accurate body composition measurement

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dietary Pattern Scores	At baseline (single assessment)	Scores derived from dietary intake assessment to evaluate overall dietary patterns of participants
Body Composition (Fat Mass, Fat-Free Mass)	At baseline (single assessment)	Measured using BOD POD to determine body fat percentage, fat mass, and fat-free mass
Hair Zinc Concentration	At baseline (single assessment)	Zinc concentration measured from hair samples as an indicator of long-term zinc status
Blood Pressure	At baseline (single assessment)	Systolic and diastolic blood pressure are measured to assess cardiovascular health status

Secondary Outcome Measures

Name	Time	Method
Inflammatory Biomarker Levels (TNF-α in Serum)	At baseline (single assessment)	Serum TNF-α measured as a marker of inflammation, assessed in approximately 30% of total participants (sub-sample)

Trial Locations

Locations (1)

Human Nutrition Research Center (HNRC) Laboratory, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 🇮🇩 Jakarta Pusat, DKI Jakarta, Indonesia