Effects of Low Dose Aspirin Pre-treatment on Platelet Activation Undergoing Off-pump Coronary Artery Bypass Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- change from baseline in platelet p-selectin at 48 hours after operation
研究概览
简要总结
Platelet activation after off pump coronary artery bypass (OPCAB) surgery may affect thrombus formation. The purpose of this study is to assess the effects of preoperative continuation of aspirin on platelet activation after off pump coronary artery bypass surgery.
详细描述
Patients undergoing OPCAB surgery will be randomized to continue preoperative aspirin or discontinue aspirin before surgery.
Platelet activation can be evaluated by measuring platelet p-selectin using flowcytometry. In this study, we will compare platelet-activated markers and conventional coagulation tests.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age : 20-80
- •elective OPCAB
- •informed consent
排除标准
- •coagulation disorder
- •emergency operation, re-operation
- •co-existing valvular disease
- •less than 6 months after cerebral vascular accident
- •heparin induced thrombocytopenia
- •heparin resistance
- •menstrual phase
- •preoperative cardiopulmonary bypass, continuous veno-veno hemofiltration, intra-aortic balloon pump application
- •less than 12 months after myocardiac infarction
- •less than 10 days after unstable angina
- •less than 30 days after percutaneous coronary intervention
- •less than 6 wks after bare metal stent insertion
- •less than 12 months after drug eluting stent insertion
研究组 & 干预措施
aspirin continuation
Intervention : Low-dose aspirin (< 100mg/day) is used before OPCAB surgery in the aspirin continuation group.
干预措施: aspirin continuation (Drug)
aspirin discontinuation
Intervention: Low-dose aspirin is stopped more than 4 days before OPCAB surgery in the aspirin discontinuation group.
干预措施: aspirin discontinuation (Drug)
结局指标
主要结局
change from baseline in platelet p-selectin at 48 hours after operation
时间窗: after induction of anesthesia(baseline), at the time of end of operation, 24 hour after operation, 48hr after operation
Primary outcome is expression of platelet p-selectin measured by flowcytometry 48 hours after OPCAB surgery in both groups.
次要结局
- change from baseline in conventional coagulation tests at the time of end of operation, 24 hour after operation, and 48hr after operation(after induction of anesthesia(baseline), at the time of end of operation, 24 hour after operation, 48hr after operation)