Classical conditioning of intranasal insulin in healthy humans
Phase 1
- Conditions
- We examined only healthy subjectsApplication for prevention and treatment of adiposity might be considered
- Registration Number
- DRKS00000537
- Lead Sponsor
- niversität Düsseldorf, Klinik für Endokrinologie, Diabetologie und Rheumatologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 32
Inclusion Criteria
healthy male students
Exclusion Criteria
Diabetes (also parents and siblings), allergies, chronic and/or acute rhinitis, diseases and anatomic deviations of the nose, chronic diseases: i.e., cardiovascular disorders; endocrine disorders and neurological diseases, especially seizures, chronic diseases of liver and kidneys, and other chronic diseases; medication with glucocorticoids and psychopharmacological drugs, substance abuse (alcohol, drugs); smoking; athelets were excluded
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br>Food-intake behavior (calorie intake) as a reduction in a standardized test meal in the exreimental- compared to the control group; <br><br>Blood glucose and peripheral insulin under euglycemia: Relative to baseline: cumulative change of blood glucose (11 measurement poits) and insulin (6 measurement points) in the experimental- compared to the control group
- Secondary Outcome Measures
Name Time Method Peripheral leptin, cortisol, epinephrine, norepinephrine: Cumulative change of the hormones in the experimental- compared to the control group (measurement points see insulin)<br><br><br>Memory: Scores in psychometric test (Lern- und Gedächtnistest LGT-3) in the experimental- compared to the control group; <br><br>EEG: acousticall-evoked potentials in the experimental group compared to the control group (1 measuremnt point baseline, 3 meaurement points during intranasal treatment)<br>