The effects of intranasal insulin on glucose metabolism in healthy me
- Conditions
- Diabetes10018424
- Registration Number
- NL-OMON33430
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Healthy men, ages between 18 and 35 years, BMI between 20 and 25 kg/m2, with a normal oral glucose tolerance test.
Exclusion Criteria
* any medication or substance use
* diabetes mellitus II (DM II) in first degree family members
* smoking
* alcohol abuse ( >3/day)
* lipid disorders, renal insufficiency, elevated liver enzymes or TSH
* bleeding disorders
* prior surgery of the nose and/or septum
* allergic rhinitis
* known allergies to antibiotics, used as prophylaxis in this study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Endogenous glucose production.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Insulin concentration in de cerebrospinal fluid<br /><br>glucoregulatory hormones</p><br>