Timing of HCG Administration in IUI Cycles
- Registration Number
- NCT02330705
- Lead Sponsor
- Mohamed Ibrahem Eid
- Brief Summary
Evaluation of the effect of altering the timing of human chorionic gonadotropin (HCG) administration on the clinical pregnancy rate in intrauterine insemination (IUI) cycles.
- Detailed Description
Women will be randomly divided into 3 groups; the first group will undergo IUI at the time HCG administration, the second group will undergo IUI 12 hours after HCG administration and the third group will undergo IUI 34-36 hours after HCG administration.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 225
- Mild male factor infertility or unexplained infertility.
- Advanced male factor infertility.
- Polycystic ovary syndrome (PCOS) as defined by the Rotterdam criteria.
- Endometriosis.
- Tubal disease.
- Uterine abnormalities or myoma.
- Previous uterine surgery.
- Metabolic or hormonal abnormalities.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group A HCG IUI at time of HCG Group B HCG IUI 12 hours after HCG Group C HCG IUI 34-36 hours after HCG
- Primary Outcome Measures
Name Time Method Clinical pregnancy rate 4-6 weeks after IUI Number of clinical pregnancies (defined as presence of at least one intrauterine gestational sac with fetal pole and cardiac activity on TVS scan at 4-6 weeks after IUI) divided by the number of IUI cycles
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Fertility care unit (FCU) in Mansoura University Hospitals
🇪🇬Mansourah, Dakahlia, Egypt
Private fertility care centers
🇪🇬Mansourah, Dakahlia, Egypt