Comparison of two protocols for transfer of the frozen embryos
- Conditions
- infertility.Postprocedural disorders of genitourinary system, not elsewhere classified
- Registration Number
- IRCT201107266420N4
- Lead Sponsor
- Yazd reaserch and clinical center for infertility
- Brief Summary
Abstract Background: Human chorionic gonadotropin (HCG), one of the initial embryonic signals, is probably a major regulator of the embryo-endometrial relationship. This study aims to assess the advantage of HCG supplementation during the secretory phase of hormonally prepared cycles for the transfer of cryopreserved-thawed embryos. Materials and Methods: This study was a randomized clinical trial. Infertile women who were candidates for frozen-thawed embryo transfers entered the study and were divided into two groups, HCG and control. The endometrial preparation method was similar in both groups: all women received estradiol valerate (6 mg) po per day from the second day of the menstrual cycle and progesterone in oil (100 mg) intramuscular (I.M.) when the endometrial thickness reached 8 mm. Estradiol and progesterone were continued until the tenth week of gestation. In the HCG group, patients received an HCG 5000 IU injection on the first day of progesterone administration and the day of embryo transfer. Results: In this study, 130 couples participated: 65 in the HCG group and 65 in the control group. There was no statistically significant difference between groups regarding basic characteristics. Implantation rate, chemical pregnancy, clinical pregnancy, ongoing pregnancy, and abortion rates were similar in both groups. Conclusion: Although HCG has some advantages in assisted reproductive technology (ART) cycles, our study did not show any benefit of HCG supplementation during the secretory phase of frozen cycles (Registration Number: IRCT201107266420N4). Keywords: ART, Implantation, Frozen Embryo, HCG
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 150
History of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) fail; cryopreservation of excess embryos
age >38 years; BMI>30; history of endocrine disorder; severe endometriosis.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Chemical pregnancy. Timepoint: 2 weeks. Method of measurement: serum BHCG.
- Secondary Outcome Measures
Name Time Method Clinical sonography. Timepoint: 2 weeks. Method of measurement: sonography.