Calcium and Magnesium Infusion for the Prevention of Taxane Induced Neuropathy
- Conditions
- Paclitaxel-induced Neuropathy
- Interventions
- Registration Number
- NCT01682499
- Lead Sponsor
- Beth Israel Medical Center
- Brief Summary
This is a pilot study evaluating the feasibility of intravenous calcium and magnesium (Ca/Mg) infusion for prevention of taxane induced neuropathy in patients with early stage breast cancer receiving adjuvant or neo-adjuvant paclitaxel, either given every 2 weeks for 4 cycles or every week for 12 weeks.
- Detailed Description
Chemotherapy induced peripheral neuropathy (CIPN) is a major dose limiting side effect of many cytotoxic chemotherapy, and can be extremely disabling, causing significant loss of functional abilities. Calcium and magnesium infusions were shown to decreased the incidence and intensity of neuropathy symptoms related to oxaliplatin.
There are currently no effective drugs or treatment modalities for the prevention or treatment of taxane related neuropathy. Given the morbidity of taxane induced neuropathy and the safety of Ca/Mg infusion, it is reasonable to assess the feasibility of this intervention in woman with stage I-III breast cancer receiving adjuvant or neo-adjuvant paclitaxel treatment, either given every 2 weeks for 4 cycles or every week for 12 weeks. Calcium gluconate and magnesium sulfate, 1 g of each agent in 100 ml D5W will be infused over 30 minutes, immediately before and after each dose of paclitaxel. The Ca/Mg infusion will be given through the same line used for giving chemotherapy.
The primary aim of this study is to assess paclitaxel-related neuropathy (grade 2 or greater) as measured by NCI Common Terminology Criteria Version 3 in patients receiving Ca/Mg infusion during paclitaxel chemotherapy and compare it with historical controls. Secondary endpoints will include other measures of neuropathy and quality of life such as the FACT-Tax score, taxane-related neuropathy pain as measured by the Brief Pain Inventory-Short Form (BPI-SF), and measure of cognitive impairment using FACT-cog score.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- Age > 21 years
- History of stage I-III breast cancer
- Patient scheduled to be receiving adjuvant or neo-adjuvant paclitaxel given every week for 12 weeks or given every two weeks for 4 cycles
- Serum magnesium level ≤ UNL
- Serum calcium level ≤ UNL
- Serum creatinine ≤ 1.5 x UNL
- Signed informed consent
- Pre-existing peripheral neuropathy of any grade
- Current treatment for arrhythmias
- Concurrent treatment with anticonvulsants, tricyclic antidepressants, or other neuropathic medications such as carbamazepine, phenytoin, gabapentin, lamotrigine, or concurrent treatment with other neuropathic chemotherapy agents
- Current narcotic use
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Calcium and Magnesium Infusion calcium gluconate and magnesium sulfate -
- Primary Outcome Measures
Name Time Method to assess paclitaxel-related neuropathy (grade 2 or greater) 2 years The primary aim of this study is to assess paclitaxel-related neuropathy (grade 2 or greater) as measured by NCI Common Terminology Criteria Version 3 in patients receiving Ca/Mg infusion during paclitaxel chemotherapy and compare it with historical controls
- Secondary Outcome Measures
Name Time Method Other measures of neuropathy and quality of life 2 years The secondary endpoints will include other measures of neuropathy and quality of life such as the FACT-TAX score
Taxane-related neuropathic pain 2 years Taxane-related neuropathic pain as measured by the Brief Pain Inventory-Short Form (BPI-SF)
Measure of cognitive impairment 2 years Measurement of cognitive impairment using FACT-Cog score
Trial Locations
- Locations (3)
Beth Israel Medical Center
🇺🇸New York, New York, United States
Beth Israel Comprehensive Cancer Center
🇺🇸New York, New York, United States
St. Luke's Roosevelt Hospital Center
🇺🇸New York, New York, United States