Differences in response of hemodynamic parameters between pregnant and non-pregnant women during a cardiopulmonary exercise test.
Completed
- Conditions
- Pregnancy10026908
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
- 20 pregnant women, <13 weeks pregnant
- 20 non-pregnant women
- Age 18-40 years
Exclusion Criteria
- Any known pre-existing cardiovascular, respiratory, hypertensive or systemic disorder
- Orthopaedic impairment that compromises exercise performance
- History of placenta-related pregnancy complications (PPC)
- Multiple pregnancy
- Smoking or quit smoking <3 months
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Differences in response of cardiac output (*CO) during a CPET, measured with<br /><br>ICG (by Physioflow), between pregnant and non-pregnant women. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Differences in (response of) hemodynamic parameters, ventilation parameters and<br /><br>aerobic capacity during and after a CPET (measured with ICG, breath-by-breath<br /><br>analysis, a finger prick blood sampling and a pulse oximeter) between pregnant<br /><br>women and non-pregnant women. The parameters that will be measured or<br /><br>calculated are:<br /><br><br /><br>- Heart rate<br /><br>- Blood pressure<br /><br>- Stroke volume<br /><br>- Left cardiac function<br /><br>- Systemic vascular resistance<br /><br>- Velocity index<br /><br>- Sensitivity index submaximal (VO2 / stroke volume index)<br /><br>- Oxygen saturation<br /><br>- Gas exchange (VO2 and VCO2)<br /><br>- PetCO2 (End Tidal CO2)<br /><br>- EqCO2 (Equivalent CO2)<br /><br>- Anaerobic treshold<br /><br>- Lactate level in capillary blood </p><br>