Slow initial beeta-lactam infusion, and high-dose paracetamol to improve the prognosis of childhood bacterial meningitis, especially of pneumococcal meningitis

Completed

• Conditions: Childhood bacterial meningitis; Infections and Infestations; Meningitis

• Registration Number: ISRCTN62824827
• Lead Sponsor: uanda Hospital (Angola)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10-04
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 750

Inclusion Criteria

[Added as of 22/01/2008: All children aged at least 2 months with suspected or confirmed bacterial meningitis.]

Diagnosis:
BM is defined as a case with:
1. Positive CSF culture, or
2. Symptoms and signs compatible with bacterial meningitis, and positive blood culture, or
3. Symptoms and signs compatible with bacterial meningitis, and at least two of the following criteria:
3.1. CSF pleocytosis more than or equal to 100 cells/mm^3
3.2. A positive Gram-stain result
3.3. Positive latex agglutination test
3.4. Serum C-Reactive Protein (CRP) more than or equal to 40 mg/l, or
4. Symptoms and signs compatible with bacterial meningitis, and positive CSF antigen detection by Polymerase Chain Reaction (PCR)

Exclusion Criteria

The exclusion criteria comprise the age less than two months, trauma, or relevant underlying illness such as intracranial shunt, previous neurological disease (cerebral palsy, Down's syndrome, meningitis), previous hearing impairment if known, and immunosuppression, except Human Immunodeficiency Virus (HIV) infection.

Study & Design

• Study Type: Interventional
• Study Design: Not specified