COMPARATIVE ANALYSIS OF NEBULIZED ROPIVACAINE (0.75%) WITH NEBULIZED LIGNOCAINE (2%) ON ATTENUATION OF INTUBATION RESPONSE AND POST OPERATIVE SORE THROAT:A RANDOMIZED DOUBLE BLIND STUDY
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To compare Changes in Heart Rate,Blood Pressure (MAP)during intubation between two groups
研究概览
简要总结
This prospective, randomized, double-blind clinical study compares nebulized ropivacaine(0.75%) with lignocaine (2%) for attenuating haemodynamic responses during intubation and reducing postoperative sore throat in patients undergoing general anaesthesia.Sixty patients aged 18-65 years (ASA I/II) will be enrolled and randomly assigned to either group.Hemodynamic parameters (HR,BP,MAP),incidence of cough and severity of sore throat will be assessed at predefined time points.The study aims to identify the more effective agent for improving patient comfort and stability during airway management.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.ASA Grade I and II 2.Scheduled for elective surgery under general anaesthesia 3.Provided written informed consent.
排除标准
- •ASA Grade III and IV
- •History of cardiovascular disease 3.BMI less than 20 or more than 30 4.Pregnancy or Lactation 5.Allery to local anaesthetics
- •Anticipated difficult airway 7.Duration of surgery more than 3hrs 8.Surgical complications (e.g.,dura puncture,bleeding).
结局指标
主要结局
To compare Changes in Heart Rate,Blood Pressure (MAP)during intubation between two groups
时间窗: T0 - baseline before nebulization | T1 - after nebulization | T2 - before laryngoscopy | T3 - 1 minutes after laryngoscopy | T4 -3 minutes after intubation | T5 - 5 minutes after tracheal intubation | T6 – 7 minutes after tracheal intubation | T7 - 10 minutes after intubation
次要结局
- 1.Severity of Postoperative sore throat (POST)(2.Incidence and Severity of cough during extubation)
研究者
Dr Ambika Singh
Ananta Institute of Medical Sciences and Research Center