Quality of life and burden of disease in patients with hypoparathyroidism after thyroid surgery in the Southwestern region of the Netherlands.

Recruiting

• Conditions: hypoparathyroidism; inadequate secretion of parathyroid hormone; 10033949

• Registration Number: NL-OMON49191
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 225

Inclusion Criteria

- Patients who are aged 18 years or older at the time of inclusion
- Patients who gave informed consent
- Both cases and controls underwent (completion) thyroidectomy
- Cases have persisting hypoparathyroidism according to the previously
mentioned definition and controls do not

Exclusion Criteria

- Patients who are not able to provide written informed consent
- No adequate understanding of the Dutch language
- Parathyroid disease or parathyroid surgery

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study endpoints are quality of life in patients with hypoparathyroidism as<br /><br>measured by the physical component score of the SF-36. Other endpoints are<br /><br>cognitive and functional outcomes and burden of disease (eg. extra visits,<br /><br>employment status, comorbidities). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary objectives of this study are:<br /><br>- To determine the Thyroid-Related quality of life in patients with<br /><br>hypoparathyrodism<br /><br>- To determine the cognitive and functional outcomes in patients with<br /><br>hypoparathyrodism<br /><br>- To determine the burden of disease in patients with hypoparathyroidism (eg.<br /><br>Medication use, the absence of work/return to work, extra hospital visits,<br /><br>comorbidities, hypoparathyroidism related laboratory parameters)</p><br>