DRKS00003317尚未招募不适用

Molecular Imaging of inflammatory joint pathologies of the hand in rheumatoid arthritis patients with Hybrid-PET-SPECT

niversitätsklinikum DüsseldorfInstitut für Diagnostische und Interventionelle Radiologie0 个研究点目标入组 30 人开始时间: 2011年11月9日最近更新: 2024年8月19日

适应症

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•New diagnosed rheumatoid arthritis according to the 2010 ACR/EULAR criteria, disease duration < 6 month, inflammatory involvement of at least one metacarpophalangeal joint or at least one proximal interphalangeal joint

•1) Present malignant disease or history of malignant disease in the last five years (not basal cell carcinoma or squamous cell carcinoma of the skin or in situ carcinoma of the cervix).
•2) History of any kind of severe cardiac disease (e.g. decompensated heart insufficency, history of myocardial infarction in the last 12 month, unstable angina pectoris or unregulated hypertension).
•3) Severe pulmonary disorder.
•4) History of immunodeficiency syndroms (HIV or other) or any rheumatic disease (if not RA) or any demyelinating CNS disease (e.g. MS)
•5) History of live vaccination in the past 4 weeks prior to screening. 6) Intraarticular injections in in joints of the surveyed hand (< 4 weeks prior to screening). 7) Any kind of acute or chronic infection (e.g. Hepatitis A,B,C) or predisposition for an infection (e.g. ulcera, diabetes mellitus). 8) Renal disorders (Kreatinin 175 µmol/l, GFR < 30 mg/dl) 9) Zirrhosis or fibrosis of the liver or inadequate liver function. 10) Psychiatric disorders if limting the understanding of participatance in this study 11) Breast feading or Pregnancy. 12) General contradictions against MRI examinations (e.g. implanted cardiac pacemaker/ defibrillator, claustrophobia)

发起方

niversitätsklinikum DüsseldorfInstitut für Diagnostische und Interventionelle Radiologie