ROLE OF BCG VACCINATION AS BOOSTER ON SALMONELLA TYPHI VACCINE

Recruiting

• Conditions: 10004018; efficacy of vaccine; vaccination respons

• Registration Number: NL-OMON37465
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Healthy medical students who are scheduled to go on clinical rotation in developing countries and need to be vaccinated with BCG and typhoid fever vaccine

Exclusion Criteria

Subjects should not come from a Salmonella typhi endemic country and are not allowed to use any medication except oral anticonception drugs.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The following parameters are compared between two groups: cytokine production<br /><br>and antibody titers against salmonella typhi Vi antigen on different time<br /><br>points after vaccination.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Gene polymorphisms are analyzed and correlated with innate immunity function </p><br>