A Randomized Trial Comparing Multi-Detector Coronary CT Angiography and Stress Myocardial Perfusion Imaging as the Initial Test for the Diagnosis of Coronary Artery Disease in Intermediate Risk Patients Admitted for Chest Pain

Montefiore Medical Center1 site in 1 country400 target enrollmentJuly 2008

ConditionsCoronary Artery Disease Angina Pectoris Unstable Angina Acute Coronary Syndrome

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Coronary Artery Disease
Sponsor: Montefiore Medical Center
Enrollment: 400
Locations: 1
Primary Endpoint: Coronary catheterization that does not lead to re-vascularization
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with coronary artery disease to select appropriate candidates for coronary catheterization and re-vascularization.

Registry

clinicaltrials.gov

Start Date

July 2008

End Date

December 2013

Last Updated

10 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Montefiore Medical Center

Responsible Party

Principal Investigator

Jeffrey Levsky

Associate Director of Research

Montefiore Medical Center

Eligibility Criteria

Inclusion Criteria

•patient admitted for chest pain or pressure
•patient at intermediate short term risk of MI or death (AHA/ACC guidelines)

Exclusion Criteria

•prior diagnosis of coronary artery disease
•evidence of ongoing myocardial infarction (and other high risk criteria per AHA/ACC guidelines)
•contraindications to EKG-gated CT scanning with iodinated intravenous contrast under beta-blockade
•pregnancy
•presence of an implanted pacemaker or defibrillator
•stress myocardial perfusion imaging, coronary CTA or coronary catheterization within the last 6 months

Outcomes

Primary Outcomes

Coronary catheterization that does not lead to re-vascularization

Time Frame: 1 year

Secondary Outcomes

Death (all cause)(1 year)
Length of Hospital Stay (time to discharge)(usually from hours to a few days (average about one day))
Non-fatal myocardial infarction(1 year)
Post-test renal dysfunction(usually within a few days)