NCT00705458已完成不适用
A Randomized Trial Comparing Multi-Detector Coronary CT Angiography and Stress Myocardial Perfusion Imaging as the Initial Test for the Diagnosis of Coronary Artery Disease in Intermediate Risk Patients Admitted for Chest Pain
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 400
- 试验地点
- 2
- 主要终点
- Coronary catheterization that does not lead to re-vascularization
研究概览
简要总结
The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with coronary artery disease to select appropriate candidates for coronary catheterization and re-vascularization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient admitted for chest pain or pressure
- •patient at intermediate short term risk of MI or death (AHA/ACC guidelines)
排除标准
- •prior diagnosis of coronary artery disease
- •evidence of ongoing myocardial infarction (and other high risk criteria per AHA/ACC guidelines)
- •contraindications to EKG-gated CT scanning with iodinated intravenous contrast under beta-blockade
- •pregnancy
- •presence of an implanted pacemaker or defibrillator
- •stress myocardial perfusion imaging, coronary CTA or coronary catheterization within the last 6 months
研究组 & 干预措施
CTA
Experimental
Initial EKG-gated computed tomography angiography of the coronary arteries
干预措施: Coronary Computed Tomography Angiography (Procedure)
MPI
Active Comparator
Initial nuclear stress myocardial perfusion imaging
干预措施: Stress Nuclear Myocardial Perfusion Imaging (Procedure)
结局指标
主要结局
Coronary catheterization that does not lead to re-vascularization
时间窗: 1 year
次要结局
- Death (all cause)(1 year)
- Length of Hospital Stay (time to discharge)(usually from hours to a few days (average about one day))
- Non-fatal myocardial infarction(1 year)
- Post-test renal dysfunction(usually within a few days)
研究者
Jeffrey Levsky
Associate Director of Research
Montefiore Medical Center
研究点 (2)
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