Exendin PET/CT for imaging of paragangliomas

Phase 2

Recruiting

• Conditions: Paraganglioma; 10014713

• Registration Number: NL-OMON50901
• Lead Sponsor: ucleaire geneeskunde en radiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

• Proven PGL with a single tumor detected using standard diagnostic imaging
• No evidence of metastatic disease
• SSTR PET performed
• Scheduled for surgery
• Able to sign informed consent

Exclusion Criteria

• Breast feeding
• Pregnancy or the wish to become pregnant within 1 month
• Calculated creatinine clearance below 40ml/min
• Evidence of other malignancy than PGL in conventional imaging (suspicious
liver, bone and lung lesions)
• Age < 18 years
• Not able to sign informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Detection rate of PGLs using 68Ga-exendin-4 PET/CT</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Optimal timepoint for imaging PGLs using 68Ga-exendin-4 PET/CT.<br /><br>• Comparison of quantitative imaging parameters (SUV, tumor-to-background<br /><br>ratio, contract-to-noise ratio) between 68Ga-exendin-4 PET and SSTR PET.<br /><br>• Correlation between GLP-1R expression and tracer uptake in the PGLs.<br /><br>• Correlation quantitative imaging results and IHC data to the genetic origin<br /><br>of the PGLs.</p><br>