Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients

Not Applicable

• Conditions: Alzheimer Disease; Depression
• Interventions: Device: high-density electroencephalography

• Registration Number: NCT02840045
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

The purpose of this study is to use a new method to differentiate mnesic abilities of early alzheimer patients and patients with a depressive disorder.

This method is based on the recording of cerebral activity while patients listen to familiar, unfamiliar and newly-learned music.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-02-20
• Study First Submitted: 2016-07-12
• Study First Submitted QC: 2016-07-18
• Study First Posted: 2016-07-21
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-08
• Last Update Posted: 2017-08-09
• Primary Completion: 2018-08-20
• Study Completion: 2018-08-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Being right-handed
• recorded consent
• For Alzheimer patients: Mini Mental Status Examination (MMSE) score >= 18
• For patients with a depressive disorder : Major Depressive Disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM IV) and Montgomery-Asberg depression rating scale (MADRS) score >= 25
• For healthy controls : no cognitive deficit, MADRS score < 25, no depressive disorder according to DSM IV

Exclusion Criteria

• Auditory deficit
• contraindication to a high-density electroencephalography exam
• refusal to participate in the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Healthy controls	high-density electroencephalography	Cerebral measurements from high-density electroencephalography are recorded in healthy controls
Alzheimer patients	high-density electroencephalography	Cerebral measurements from high-density electroencephalography are recorded in Alzheimer patients. The same protocol is applied in the 3 arms
patients with a depressive disorder	high-density electroencephalography	Cerebral measurements from high-density electroencephalography are recorded in patients with a depressive disorder. The same protocol is applied in the 3 arms

Primary Outcome Measures

Name	Time	Method
Amplitude of event-related potentials	day 1 for familiar and unfamiliar songs and day 14 for newly learned songs	Measurements of the amplitude of event-related potentials with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs

Secondary Outcome Measures

Name	Time	Method
Spectral power	day 1 for familiar and unfamiliar songs and day 14 for newly learned songs	Measurements of the spectral power with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs

Trial Locations

Locations (1)

CHRU Besançon; 🇫🇷 Besancon, Franche-Comte, France