Leptin and Ghrelin in ICU
Phase 4
Completed
- Conditions
- Critically Ill
- Registration Number
- NCT02282501
- Lead Sponsor
- özgür yağan
- Brief Summary
Enteral alimentation is the preferred modality of support in critical patients who have acceptable digestive function and are unable to eat orally, but the advantages of continuous versus intermittent administration are surrounded by controversy.
This prospective, randomised study was designed to compare two enteral feeding methods with respect to changes in levels of leptin and ghrelin in ICU.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- who were unable to ingest an oral diet
- given decision on enteral feeding
Exclusion Criteria
- Carcinomatosis
- irreversible coma
- death or discharge before 14 days of observation
- contraindication to enteral feeding
- intolerance to the prescribed nutrients or infusion regimen
- burn
- multiple trauma
- morbid obesity
- end stage liver or renal or lung disease
- severe sepsis or septic shock
- patients with percutaneous endoscopic gastrostomy
- immunosuppressive drug use
- severe hemodynamic instability
- massive blood transfusion
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change from baseline in serum leptin concentration at three weeks in ICU first, 7th, 14th and 21th day Change from baseline in serum ghrelin concentration at three weeks in ICU first, 7th, 14th and 21th day in ICU
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital
🇹🇷Altınordu, Ordu, Turkey
Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital🇹🇷Altınordu, Ordu, Turkey