Amphetamine for stroke recovery: a clinical and magnetic resonance imaging study

Completed

• Conditions: Stroke; Circulatory System; Cerebrovascular diseases

• Registration Number: ISRCTN12247669
• Lead Sponsor: Sunnybrook Health Sciences Centre (Canada)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-03-30
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 71

Inclusion Criteria

1. Female or male, 30 to 65 year old
2. Ischaemic hemispheric stroke patients with moderate to severe hemiparesis
3. Medically able to participate in a rehabilitation program and expected to survive three months post-stroke
4. Pre-morbid modified Rankin score zero or one
5. Informed consent from patient or substitute decision maker

Exclusion Criteria

1. Brainstem or cerebellar stroke
2. Primary intracerebral haemorrhage
3. Pre-existing neurologic deficit (e.g. from prior stroke) that could interfere with assessments
4. Pregnancy and lactation
5. Prior history of dementia
6. Known hypersensitivity to sympathomimetic amines
7. Unstable cardiac arrhythmia or hypertension not controlled by medication (greater than 170/105 mmHg)
18. History of psychosis or tic disorder
19. Untreated hyperthyroidism
20. Concomitant use of alpha-adrenergic antagonists or agonists
21. Concomitant use of monoamine oxidase inhibitors or use within the preceding 14 days

Study & Design

• Study Type: Interventional
• Study Design: Not specified