The impact of whole body heating on blood flow distribution and temperature regulation in chronic heart failure patients
Not Applicable
Withdrawn
- Conditions
- ew York Heart Association Class I-III chronic heart failure (aetiology either ischaemic or idiopathic dilated cardiomyopathy)New York Heart Association Class I-III chronic heart failure (aetiology either ischaemic or idiopathic dilated cardiomyopathy)Cardiovascular - Other cardiovascular diseases
- Registration Number
- ACTRN12613000361707
- Lead Sponsor
- Royal Perth Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Patients with New York Heart Association Class I-III CHF (aetiology either ischaemic or idiopathic dilated cardiomyopathy)
A group of subjects who do not have CHF will be recruited as controls. These control subjects will be matched for age, sex and body composition.
Exclusion Criteria
Recent history of syncope (past 6 months)
Systolic blood pressure < 90mmHg
New York Heart Association Class IV
Recent exacerbation of heart failure resulting in hospitalisation (< 2months)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Brachial, carotid and cerebral artery blood flow asssesed by high resolution ultrasonography[At baseline prior to randomisation and following the 10 week intervention. Additionally measurements will be taken at fortnightly intervals during the intervention.];Skin blood flow assessed by microdialysis infusion of locally acting blocking agents and laser Doppler flowmetry.[At baseline prior to randomisation and following the 10 week intervention. Additionally measurements will be taken at fortnightly intervals during the intervention.];Sweat rate production assessed by a water vapour vapour pressure sensitive capacitor.[At baseline prior to randomisation and following the 10 week intervention. Additionally measurements will be taken at fortnightly intervals during the intervention.]
- Secondary Outcome Measures
Name Time Method Skin and core body temperature assessed using external (skin) and internal (rectal) thermistors.[At baseline prior to randomisation and following the 10 week intervention. Additionally measurements will be taken at fortnightly intervals during the intervention.]