Acute heat and hepatic insulin sensitivity
- Conditions
- glucose metabolism
- Registration Number
- NL-OMON28520
- Lead Sponsor
- Maastricht University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 14
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
•Signed informed consent
•Men and women
•Caucasian / white western European
•Aged 40-70 years at the start of the study
•Body mass index (BMI) 25-35 kg/m2
•Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3
•months
•Stable sedentary lifestyle (not more than 2 hours of sports per week)
•Women after their menopause, meaning no menstrual cycle for at least 24 months and only if they are not under hormonal treatment.
•Generally healthy, no medication use that interferes with metabolism. If volunteers need medication, it will be reviewed with the dependent physician on individual basis.
A potential subject who meets any of the following criteria will be excluded from participation in this study:
•Haemoglobin <8.4mmol/L
•Use of cholesterol or lipid-lowering medication
•Active pregnancy
•No signs of active uncontrolled hypertension, liver or kidney malfunction
•Cardiac problems and cardiovascular diseases, such as angina pectoris, cardiac infarction and arrhythmias
•Any medical condition requiring treatment and/or medication that might interfere with the investigated parameters. All medical conditions/medications will be reviewed with the dependent physician and in-/exclusion will be decided on individual basis
•Anticoagulation medication
•Unstable body weight (weight gain or loss >3kg in the past three months)
•Participation in another biomedical study within 1 month prior to screening visit
•Participants, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informed, cannot participate in this study
•Blood donation three months prior to study and three months after finishing the study
•Alcohol consumption of >2 servings per day Smoking in the past 6 months
•Women if they don’t take oral contraceptives for at least 3 menstrual cycle
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method hepatic insulin sensitivity
- Secondary Outcome Measures
Name Time Method substrate utilisation