The effect of acute whole-body heat exposure on liver insulin sensitivity and substrate metabolism

Completed

• Conditions: Glucose metabolism; suger metabolism; 10018424

• Registration Number: NL-OMON47966
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 14

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
* Signed informed consent
* Men and women
* Caucasian / white western European
* Aged 45-65 years at the start of the study
* Body mass index (BMI) 27-35 kg/m2
* Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3
months
* Stable sedentary lifestyle (not more than 2 hours of sports per week)
* Women after their menopause, meaning cessation of menses for at least 24
months) and only if they are not under hormonal treatment
* Suitable veins for cannulation or repeated venapuncture
* Generally healthy, no medication use that interferes with metabolism, no
signs of active cardiovascular disease, liver or kidney malfunction. If
volunteers need medication, it will be reviewed with the dependent physician on
individual basis.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:

* Type 2 Diabetes
* Men Haemoglobin <8.4mmol/L, women haemoglobin <7.8 mmol/L
* Signs of active uncontrolled hypertension, liver or kidney malfunction
* Cardiac problems and cardiovascular diseases, such as congestive heart
failure, angina pectoris, cardiac infarction and arrhythmias
* Any medical condition requiring treatment and/or medication that might
interfere with the investigated parameters. All medical conditions/medications
will be reviewed with the dependent physician and in-/exclusion will be decided
on individual basis
* Unstable body weight (weight gain or loss >3kg in the past three months)
* Participation in another biomedical study within 1 month prior to screening
visit
* Participants, who do not want to be informed about unexpected medical
findings, or do not wish that their treating physician will be informed, cannot
participate in this study
* Blood donation three month prior to study and three month after finishing
study
* Alcohol consumption of >2 servings per day for men and >1 serving per day for
women
* Smoking in the past 6 months

A medical doctor will judge participation eligibility based on the medical
history questionnaire, medication use and fasting blood parameters. If the
medical doctor advises that someone cannot participate, they will be excluded
from enrolment.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Assess the effect of acute, passively administered whole-body heat exposure on<br /><br>* hepatic insulin sensitivity<br /><br>* whole-body substrate oxidation<br /><br>* plasma metabolites. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Assess the effect of acute, passively administered whole-body heat exposure on<br /><br>* measures of thermophysiology,<br /><br>* cardiovascular parameters<br /><br>* thermal perception (thermal sensation and comfort)</p><br>