Effect of ondansetron (Anti Vomitting drug) injection on Blood pressure, heart rate in delivery by operation cases: A trial in a tertiary care institute in southern Rajastha

Not Applicable

Completed

• Conditions: Health Condition 1: O749- Complication of anesthesia duringlabor and delivery, unspecified

• Registration Number: CTRI/2022/03/041395
• Lead Sponsor: Department of Anesthesiology RNT medical college Udaipur Rajasthan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-06-29
• Last Update Posted: 9 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

Pregnant female patients, taken up for cesarean section under spinal anaesthesia for various indications like previous cesarean section, breech, oligo-hydroamnios, cephalopelvic disproportion, pregnancy following infertility treatment, post datism, cord around neck, non-progress of labour

Exclusion Criteria

Emergency indication of cesarean section like antepartum hemorrhage, placenta previa, abruptio placentae, fetal distress, obstructed labour, umbilical cord prolapse, hand prolapse, or patient in labor pains,patients having coagulation abnormalities or on anticoagulants, Patients having associated systemic illness (hypo/ hyperthyroidism, diabetic, neuromuscular diseases, ischemic/ valvular/ congenital heart diseases, psychiatric, hematological disorder),contraindications for spinal anesthesia,

history of seizures, coma, neurological signs or symptoms (Eclampsia), patient refusal to participate in study,any allergy to local anaesthetic, Obese (weight > 100 Kg), short stature (height < 150cm), with spinal deformity.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To measure the effect of ondansetron administration 20 minutes prior to spinal anesthesia on hemodynamic statusTimepoint: Every 5 minutes After spinal anesthesia till completion of Caesarian Section Intraoperative only

Secondary Outcome Measures

Name	Time	Method
To determine the preventive and therapeutic role of ondansetron on these complications i.e. Intra-operative nausea vomiting, pruritus, shivering .Timepoint: After spinal anesthesia till completion of surgery;To quantify therapeutic vasopressor dose requirement for correction of hypotension.Timepoint: After spinal anesthesia till completion of surgery