Investigating the Curcumin effects on ICU admitted traumatic brain injury patients' outcome

Phase 3

• Conditions: Traumatic brain injury.; Diffuse traumatic brain injury; S06.2

• Registration Number: IRCT20151221025641N7
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 272

Inclusion Criteria

The age of the patient is between 18 and 85 years;
The reason for admission to the intensive care unit is head trauma;
The patient or his first degree relatives have signed the consent form knowingly and freely;
Glasgow coma scale is 8 and above;
Less than 48 hours have passed since the loss of consciousness secondary to traumatic brain injury;
There is no prohibition to receive oral medications.

Exclusion Criteria

Pregnancy;
Lactation;
Not being hemodynamically and metabolically stable and needing to receive vasoactive drugs;
History of any type of disease or autoimmune disorders;
History of chemotherapy and radiotherapy in the past month;
History of any liver failure;
Active bleeding;
History of known Curcumin allergy.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
SOFA score. Timepoint: Days 0 and 7. Method of measurement: SOFA score (The Sequential Organ Failure Assessment Score) calculation.;Glasgow coma scale (GCS) score. Timepoint: Days 0 and 7. Method of measurement: Glasgow coma scale (GCS) score calculation.