Vascular Phenotypes in a Geriatric Populatio

Completed

• Conditions: dementia; vascular riskfactors; 10082206; 10012272; 10057166

• Registration Number: NL-OMON52796
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

- 65 years of age and older
- visiting the geriatric memory clinic of the VUmc
- signed informed conscent of the general protocol (METc 2017.148)

Exclusion Criteria

- Insufficient mastery of Dutch language
- Severe cognitive impairment: MMSE-score < 16.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are different vascular phenotypes, based on<br /><br>measurements of macro- and microvascular function, including intima media<br /><br>thicknes van de common carotic artery, stiffness index of carotid artery, local<br /><br>carotid pulse wave velocity, blood pressure, orthostatic hypotension,<br /><br>glomerular filtration rate, structural brain damage and arterial tonometry.<br /><br>Based on these measurements we aim to distinguish four vascular phenotypes: no<br /><br>vascular damage, both macro- and microvascular damage, only macrovascular<br /><br>damage and only microvascular damage. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are cognitive functioning, as assessed by<br /><br>neuropsychological assessment, physical functioning (handgrip strength, gait<br /><br>speed and Short Physical Performance Battery; SPPB) and functional outcomes:<br /><br>activities of daily living (ADL) and instrumental ADL (iADL) dependence levels,<br /><br>quality of life, (serious) adverse events and mortality.</p><br>