Surgical Handling of Fertility-preserving Treatments for Cervical Adenocarcinomas
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Recurrence rate
研究概览
简要总结
Despite a growing body of literature on the subject, there is still uncertainty regarding direct comparisons between different conservative surgical techniques for cervical adenocarcinomas. In particular, it remains unclear whether fertility-sparing surgery for cervical adenocarcinomas - characterized by skip lesions - can ensure optimal disease control while achieving adequate obstetric outcomes.
For this reason, a systematic review and meta-analysis of the literature, along with an analysis of our center's data, is warranted. This approach will allow a critical, comparative evaluation of the efficacy of the different techniques (conization, simple trachelectomy, and radical trachelectomy) and the identification of prognostic factors to guide therapeutic choice.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Adult women of reproductive age with a diagnosis of cervical adenocarcinoma
- •Undergoing fertility-sparing surgery
- •Minimum 12-month follow-up
- •Signed informed consent
排除标准
- •Histotypes other than cervical adenocarcinoma
- •Undergoing radical surgery
- •Follow-up less than 12 months
结局指标
主要结局
Recurrence rate
时间窗: 5 years
The recurrence rate is defined as the proportion of patients who develop disease recurrence confirmed by imaging or histopathologic evaluation after FSS.
Disease free survival
时间窗: 5 years
Disease-free survival is defined as the time from surgery until the first documented recurrence.
Overall survival
时间窗: 5 years
Overall survival is measured as the time from surgery to death from any cause,
次要结局
- pregnancy rate(5 years)
- live birth rate(5 years)