External Evaluation of Vancomycin Population Pharmacokinetic Models
- Conditions
- Vancomycin Dosage
- Registration Number
- NCT05481788
- Lead Sponsor
- University Hospital, Brest
- Brief Summary
All patients treated with vancomycin hospitalized outside of ICU in Brest University Hospital from 1rst january 2019 to 1rst january 2021 will be screened for inclusion. Vancomycin dosage, age, weight and serum creatinin will be recorded.
Seven pharmacokinetic models' predictive performance will be evaluated on this database.
Using the best model, we will perform Monte-Carlo simulation to elaborate dosing nomograms and develop dosing recommandations of continuous infusion of vancomycin.
- Detailed Description
Monte Carlo simulations will be performed according to varying creatinin clearance values and weight, for both the loading dose and the maintenance dose.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 300
- All patients hospitalized in Brest University Hospital,
- treated with vancomycin and receiving pharmacological monitoring
- between 1rst January 2019 and 1rst January 2021
- Missing data on vancomycin administration
- Refusal to be included in this study
- Hospitalisation in ICU
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Imprecision in Predictive performance of seven pharmacokinetic models September 2021 The model with the lesser imprecision reported on the Observed vs Predicted Concentrations Graph will be selected
Bias in Predictive performance of seven pharmacokinetic models September 2021 The model with the lesser bias reported on the Observed vs Predicted Concentrations Graph will be selected
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Brest University Hospital
🇫🇷Brest, France