The IDENTAKIT-HF trial: Identification of optimal markers of Acute Kidney Injury (AKI) in patients with Acute Decompensated Heart Failure (ADHF)

Not Applicable

Completed

• Conditions: acute decompensated heart failure; acute kidney injury; Cardiovascular - Other cardiovascular diseases; Renal and Urogenital - Kidney disease

• Registration Number: ACTRN12615000955516
• Lead Sponsor: Christchurch Heart Institute Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-09-11
• Study Completion: 2021-03-26
• Last Update Posted: 21 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

Provide signed and dated informed consent form
Willing to comply with all study procedures and be available for the duration of the study
Living independently (ie, not hospital care dependent)
Admitted with ADHF as evidenced by typical clinical features plus either radiological evidence of HF or an NTproBNP level >1000pg/ml.

Exclusion Criteria

A primary diagnosis of acute coronary syndrome (ACS), myocarditis/pericarditis, pericardial constriction,
A life expectancy due to non-cardiac disease of <6 months,
A concurrent severe hepatic or pulmonary disease A concurrent severe hepatic disease
Severe renal impairment (plasma creatinine >250 micromol/L),
Severe valvular disease requiring surgery,
Severe aortic stenosis (valve area <1 cm^2), or HF due to mitral stenosis
A patient under consideration for cardiac transplantation
Without a urine sample within 4 hours of admission
With a prior eGFR <15 ml/min/1.73m2
On dialysis
Unable to comply with study protocol requirements
Unwilling or unable to consent
Already actively enrolled in this study

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The Incidence of AKI in ADHF.<br>[Assessed by an increase in Serum Creatinine (SCr) by greater than or equal to 26.4 l micromol/l within any 48 hour period from admission till discharge; or an increase in SCr to greater than or equal to 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days at any point from admission to discharge.]