Determination of the optimal biomarkers in urine and hair after oral and dermal pesticide exposure in order to quantify the pesticide exposure*
Completed
- Conditions
- aandoeningen zijn geen onderdeel van deze studie. Doel is namelijk het bepalen van humane biomarkers in urine en haar.Niet van toepassing
- Registration Number
- NL-OMON43439
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 36
Inclusion Criteria
- Good general health i.e. no use of prescribed medication (except oral contraceptives);
- Age between 18 and 65 years;
- BMI between 20 and 25;
- Alcohol consumption less than two standard glasses a day;
- Caucasian (to minimize genetic differences);
Exclusion Criteria
- Pregnancy or willing to become pregnant during the study;
- Skin disorders, e.g. atopic eczema, psoriasis, or other chronic skin diseases that causes hyperkeratosis;
- Skin abnormalities on the non-dominant forearm, e.g. scars and injuries;
- Smoking;
- Direct contact or working with pesticides;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Concentration of parent compound(s) and/or its metabolite(s) in urine and hair<br /><br>after oral and dermal exposure, including relative metabolite conversion<br /><br>factors and recovery percentages. In addition, the excretion patterns of<br /><br>parents/metabolites in urine over the first 48 hours after administration will<br /><br>be determined.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable</p><br>