Role of urine tests in knowing the type of kidney damage occurring in liver disease patients
Not Applicable
- Conditions
- Health Condition 1: N17- Acute kidney failureHealth Condition 2: K74- Fibrosis and cirrhosis of liverHealth Condition 3: R188- Other ascites
- Registration Number
- CTRI/2023/11/059816
- Lead Sponsor
- Deep Patel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Decompensated Cirrhosis with ascites having AKI (=Stage IB, Serum creatinine=1.5mg/dl)
Exclusion Criteria
1)Advanced Chronic Kidney Disease
2)Prior Kidney or Liver Transplant
3)Renal Replacement Therapy at the time of enrolment
4)Pregnancy
5)Diagnosed case of Hepatocellular carcinoma
6)Extrahepatic Malignancy
7)Severe Co-morbidities (CHF, COPD)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sensitivity, Specificity, Positive predictive value, Negative predictive value and diagnostic accuracy of Urine NGAL and Urine IL-18 in decompensated cirrhotic patients having Acute Kidney injury for differentiating between ATN-AKI vs Non-ATN-AKI.Timepoint: At baseline
- Secondary Outcome Measures
Name Time Method Sensitivity, Specificity, Positive predictive value, Negative predictive value & diagnostic accuracy of Urine NGAL & Urine IL-18 in decompensated cirrhotic patients having Acute Kidney injury for differentiating between HRS-AKI vs Non-HRS-AKI.Timepoint: At baseline;Sensitivity, specificity, Positive predictive value, Negative predictive value & diagnostic accuracy of Urine NGAL & Urine IL-18 in decompensated cirrhotic patients having Acute Kidney injury for differentiating between PRA-AKI vs Non-PRA-AKI.Timepoint: At baseline