Effects of sevoflurane versus propofol on mitral annular displacement evaluated using speckle tracking.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- SCTIMST
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- To compare differences between GLS and MAPSE, mitral annular velocity with TDI and TMAD in CABG patients.
研究概览
简要总结
Left ventricular (LV) systolic function is a predictor for perioperative morbidity and mortality in patients undergoing coronary artery bypass grafting (CABG) . Patients having coronary artery disease with preserved left ventricular ejection fraction may have subclinical myocardial dysfunction possibly due to subendocardial ischemia, which is characterised by impaired global longitudinal strain. Transesophageal echocardiography (TEE) is a corner-stone for assessing LV systolic function in routine intraoperative practice. Two dimensional speckle-tracking strain (2D-STI) using echocardiographic imaging allows the angle-independent evaluation of myocardial strain in the three directions (radial, circumferential, and longitudinal), providing comprehensive information on LV myocardial contractility and may be better than other 2D based calculations of LV systolic function like ejection fraction.Tissue motion annular displacement of the mitral valve (TMAD) is a new parameter of evaluation of longitudinal systolic function of the left ventricle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •All Adult patients scheduled for elective CABG under CPB.
- •Age group between 18 – 75 years.
- •Normal sinus rhythm.
排除标准
- •Patients with other associated complex anomalies.
- •Patients with more than mild MS, MR, AS or AR.
- •Patients with severe mitral annular calcification.
- •Contraindication to TEE probe placement.
- •Patient refusing to participate in the project.
- •Poor 2D & 3D image quality Emergency and Redo surgeries.
结局指标
主要结局
To compare differences between GLS and MAPSE, mitral annular velocity with TDI and TMAD in CABG patients.
时间窗: intraoperative
To study intraoperative differences in MAPSE, mitral annular velocity with TDI and TMAD in CABG patients.
时间窗: intraoperative
To compare effects of sevoflurane and propofol anaesthesia on changes in MAPSE, mitral annular velocity with TDI and TMAD on CABG patients.
时间窗: intraoperative
次要结局
- To ascertain intraobserver and interobserver variability between TMAD and MAPSE and GLS