Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients
- Conditions
- Kidney DiseaseHypercalcemia
- Registration Number
- NCT00485706
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Brief Summary
Renal patients have an increased risk for cardiovascular complications. There is also increased vascular calcification and bone metabolism is similarly abnormal in patients with chronic kidney disease.
In dialysis patients frequent episodes of hypercalcaemia occur. In a healthy bone structure those episodes of hypercalcemia are buffered by the bone. The absence of bone buffering capacity in dialysis patients can be a mechanism for vascular calcifications.
- Detailed Description
Study hypothesis.
Patient with a higher ∆ Calcium (Calcium post - Calcium pre) have a diminished bone buffering capacity indicative for adynamic bone disease compared with patients with smaller ∆ Calcium.
This may result in higher extraosseous calcification and higher pulse wave velocity
∆ PTH/∆ Calcium may reflect the sensitivity and density of the calcium receptors; this may reflect parathyroid "health"
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
- maintenance hemodialysis patients
- dialysis <3 months
- aortobifemoral graft
- calcium level predialysis >10.5 mg/dl
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method correlation between calcium change and pth change correlation between calcium change and pth change
correlation between calcium increase and pulse wave velocity correlation between calcium increase and pulse wave velocity
- Secondary Outcome Measures
Name Time Method correlation between calcium increase and vascular calcifications correlation between calcium increase and vascular calcifications
correlation between calcium change and bone markers correlation between calcium change and bone markers
Trial Locations
- Locations (1)
UZ Gasthuisberg
🇧🇪LEuven, Belgium