A Protein Supplementation and Exercise Strategy to Promote Muscle Protein Anabolism in Frail Elderly People

Wageningen University1 site in 1 country62 target enrollmentNovember 2009

ConditionsSarcopenia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Sarcopenia
Sponsor: Wageningen University
Enrollment: 62
Locations: 1
Primary Endpoint: Change in skeletal muscle mass
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The present study is designed to investigate whether timed protein supplementation will increase skeletal muscle mass in the frail elderly population.

Registry

clinicaltrials.gov

Start Date

November 2009

End Date

July 2011

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Wageningen University

Responsible Party

Principal Investigator

Lisette de Groot

Professor

Wageningen University

Eligibility Criteria

Inclusion Criteria

•Frail elderly individuals
•Able to understand and perform the study procedures

Exclusion Criteria

•Type I or type II diabetes (fasted blood glucose level ≥7,0 mmol)
•No recent history (within 2 years) of participating in any regular resistance exercise training program (general questionnaire)
•Use of anti-coagulation medication (except of Acetyl Salicyl acid)
•Presence of coronary heart disease (ECG)
•Renal insufficiency (eGFR \<60 mL/min/1.73 m2)
•Allergic or sensitive for milk proteins

Outcomes

Primary Outcomes

Change in skeletal muscle mass

Time Frame: Baseline, 3 months and 6 months

Secondary Outcomes

Physical performance(Baseline, 3 months and 6 months)
Blood will be collected to assess parameters related to the outcome measures(Baseline, 3 months and 6 months)
Dietary intake(Baseline, 3 months and 6 months)
Physical activity(Baseline, 3 months and 6 months)
Cognitive performance(Baseline and 6 months)
Blood pressure(Baseline, 3 months and 6 months)