A Protein Supplementation and Exercise Strategy to Promote Muscle Protein Anabolism in Frail Elderly People

Not Applicable

Completed

• Conditions: Sarcopenia
• Interventions: Dietary Supplement: Protein drink; Other: Resistance exercise training; Dietary Supplement: Placebo drink

• Registration Number: NCT01110369
• Lead Sponsor: Wageningen University

Brief Summary

The present study is designed to investigate whether timed protein supplementation will increase skeletal muscle mass in the frail elderly population.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-11
• Study First Submitted: 2010-02-12
• Study First Submitted QC: 2010-04-22
• Study First Posted: 2010-04-26
• Primary Completion: 2011-07
• Study Completion: 2011-07
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-01
• Last Update Posted: 2025-04-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• Frail elderly individuals
• Able to understand and perform the study procedures

Exclusion Criteria

• Type I or type II diabetes (fasted blood glucose level ≥7,0 mmol)
• No recent history (within 2 years) of participating in any regular resistance exercise training program (general questionnaire)
• Use of anti-coagulation medication (except of Acetyl Salicyl acid)
• Presence of coronary heart disease (ECG)
• Renal insufficiency (eGFR <60 mL/min/1.73 m2)
• Allergic or sensitive for milk proteins

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Resistance exercise training and protein drink	Resistance exercise training	-
Resistance exercise training and placebo drink	Resistance exercise training	-
Resistance exercise training and protein drink	Protein drink	-
Resistance exercise training and placebo drink	Placebo drink	-

Primary Outcome Measures

Name	Time	Method
Change in skeletal muscle mass	Baseline, 3 months and 6 months

Secondary Outcome Measures

Name	Time	Method
Physical performance	Baseline, 3 months and 6 months
Blood will be collected to assess parameters related to the outcome measures	Baseline, 3 months and 6 months
Dietary intake	Baseline, 3 months and 6 months
Physical activity	Baseline, 3 months and 6 months
Cognitive performance	Baseline and 6 months
Blood pressure	Baseline, 3 months and 6 months

Trial Locations

Locations (1)

Wageningen University; 🇳🇱 Wageningen, Gelderland, Netherlands