NCT03741621已完成2 期
Viscosity Rather Than Quality of Dietary Fibre Predicts Cholesterol-lowering Effect in Healthy Individuals
适应症
干预措施
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 23
- 主要终点
- change in LDL cholesterol
研究概览
简要总结
To investigate the role of fibre viscosity (low, medium, high) in lowering cholesterol in healthy individuals
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy individuals
排除标准
- •regular alcohol consumption
- •regular smoking
研究组 & 干预措施
High Viscosity
Experimental
viscous fibre blend added to breakfast cereals consumed in the context of a typical North American diet for 3 weeks duration
干预措施: Viscous Fibre Blend (Dietary Supplement)
Low Viscosity
Experimental
Kellogg's All Bran breakfast cereal consumed in the context of a typical North American diet for 3 weeks duration
干预措施: Wheat Bran (Dietary Supplement)
Medium Viscosity
Experimental
Kellogg's Bran buds with psyllium breakfast cereal consumed in the context of a typical North American diet for 3 weeks duration
干预措施: Psyllium (Dietary Supplement)
结局指标
主要结局
change in LDL cholesterol
时间窗: change from baseline after 21 days, relative to control
次要结局
- change in apolipoprotein A-1(change from baseline after 21 days, relative to control)
- change in triglycerides(change from baseline after 21 days, relative to control)
- change in HDL cholesterol(change from baseline after 21 days, relative to control)
- change in total cholesterol(change from baseline after 21 days, relative to control)
- change in apolipoprotein B(change from baseline after 21 days, relative to control)
研究者
相似试验
Unknown
不适用
Effect of Viscous Soluble Fibers on Serum Cholesterol LevelsLDL CholesterolNCT02068248Unity Health Toronto1,000
Unknown
不适用
The Effect of Viscous Dietary Fibers on LDL-cholesterolCardiovascular Risk FactorHypercholesterolemiaNCT04133805Unity Health Toronto7,845
已完成
不适用
High- Fiber/ Low-fat Diet for Prevention of Recurrent Clostridioides Difficile Infection in OncologyLeukemia, Lymphocytic, AcuteLeukemia, Myeloid, AcuteClostridium Difficile InfectionLymphomaSolid CancersNCT04940468University of Colorado, Denver8
已完成
不适用
A Controlled Trial of High Dietary Fiber Intake on Serum LipidsHyperlipidemiaNCT00593632The Cleveland Clinic50
已完成
不适用
Investigating health effects of fibre consumption in healthy humansAsthmaInflammatory Bowel DiseaseACTRN12619000845134Monash University10