*The prevalence of Exercise Induced Laryngeal Obstruction (EILO) amongst children with asthma *
- Conditions
- 'Exercise Induced Laryngeal Obstruction (EILO)' Glottic or supraglottic narrowing of the airway during exercise10046304
- Registration Number
- NL-OMON53261
- Lead Sponsor
- Medisch Spectrum Twente
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 100
-Age 8 to 18 years old
-Outpatient at Medisch Spectrum Twente or Haukeland University Hospital
-History of paediatrician diagnosed asthma confirmed with objective lung
function measurements:
-a positive test for exercise induced bronchoconstriction (post-exercise fall
in FEV1 > 10% after exercise challenge test) OR
-a positive methacholine test (PC20 value of <=8 mg/mL) OR
-bronchodilator reversibility (increase in FEV1 >=12% and/or >=200 mL following
inhalation of 400 µg SABA )
-Other severe cardiopulmonary disease than asthma
-Inability to perform exercise test and/or technical acceptable spirometry
-Current asthma exacerbation, or exacerbation in the previous 2 weeks
-Respiratory tract infection in the previous 2 weeks
-Use of LABA or SABA less than 8 hours prior to exercise challenge test
-Use of oral corticosteroids in 4 weeks prior to exercise challenge test
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The presence of EILO based on the Maat score (glottic and/or supraglottic,<br /><br>grade 2 or higher) during the CLE test</p><br>
- Secondary Outcome Measures
Name Time Method <p>-Recognizable symptoms induced : yes/no<br /><br>-EILO grade score (Maat score; glottic and/or supraglottic)<br /><br>-Laryngeal pathology at rest<br /><br>-Exercise induced bronchoconstriction defined as post-exercise fall in FEV1 ><br /><br>10% during CLE test and during ECT beforehand. (Post-exercise fall in FEV1 =<br /><br>(FEV1pre-exercise - FEV1post-exercise) / FEV1pre-exercise * 100%).<br /><br>-Symptoms reported<br /><br>-Test duration and duration until start of symptoms and until peak dyspnea<br /><br>-Heart rate during exercise<br /><br>-Lung function with in- and expiratory flow volume loops (FEV1, FEV1(%pred),<br /><br>FVC)<br /><br>-before exercise<br /><br>-after exercise at 2 minute intervals (1,3,6 minutes)<br /><br>-Maximum running pace and slope (or max Wattage and Wattage/kg )<br /><br>-ACT score and sub scores<br /><br>-EILODI score and sub scores<br /><br>-VAS score: before exercise, at peak level of dyspnea and 2 minutes after<br /><br>exercise </p><br>